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Historical View: Early researchers described DSIP as “incredibly safe.” Animal studies failed to identify a lethal dose (LD50), and human trials reported no significant adverse events other than transient headaches or nausea

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Comparison of short-term treatment regimen of ciprofloxacin versus long-term treatment regimens of trimethoprim/sulfamethoxazole or norfloxacin for uncomplicated lower urinary tract infections: A randomized, multicentre, open-label, prospective study